About the Lab
The Barz Lab develops next-generation polymeric and lipid-based materials for advanced drug and gene delivery. The group combines precision polymer chemistry with biomedical engineering to design tailor-made nanocarriers—such as polypept(o)ide micelles, bottlebrushes, and lipid nanoparticles—that transport therapeutic molecules safely and efficiently to their targets. A major focus is on polysarcosine-based polymers as biocompatible alternatives to polyethylene glycol, offering improved stability and reduced immune reactions. The lab investigates how nanoparticle architecture, size, and surface chemistry influence biological interactions, including protein-corona formation and in-vivo stability. Applications span mRNA and siRNA therapeutics, targeted cancer therapy, and infectious-disease treatment. Students joining the Barz Lab will work at the interface of synthetic polymer chemistry, nanotechnology, and life sciences—ideal for those excited by the challenge of translating molecular design into real medical impact. Strong candidates typically enjoy experimental lab work, molecular synthesis, and interdisciplinary problem-solving that connects chemistry to human health.