About the Lab
The Bräse Lab focuses on the design and synthesis of novel bioactive small molecules with therapeutic potential, particularly targeting cancer and antimicrobial resistance. The group employs advanced organic synthesis, structure–activity relationship studies, and computational tools such as molecular docking and dynamics simulations to develop dual-target inhibitors for key proteins like EGFR, HER2, VEGFR-2, tubulin, and carbonic anhydrases. A strong emphasis is placed on understanding molecular mechanisms of action through biochemical assays, apoptosis markers, and in vitro cytotoxicity. In parallel, the lab explores smart materials and functional frameworks such as paracyclophane-based polymers and multiresonant TADF emitters for optoelectronic devices like OLEDs. This interdisciplinary approach combines medicinal chemistry, materials science, and cutting-edge spectroscopy. The Bräse Lab is ideal for students interested in synthetic organic chemistry, drug design, or materials innovation. Candidates with strong skills in lab synthesis, NMR spectroscopy, and a keen interest in molecular pharmacology or photophysics will thrive in this dynamic environment.